Hemorrhage
ADU-09
Diagnosis
Acute massive bleeding
Call for help
- Ask: "Who will be the crisis manager?"
- Crisis manager designates checklist reader
Crystalloid bolus until blood products available
Obtain large bore IV access, rapid infuser
- Obtain arterial access
Turn FiO2 to 100% and reduce volatile anesthetics
Call blood bank
- Activate massive transfusion protocol
- Consider whole blood
- Consider uncrossmatched Type O RBC and Type AB plasma
- Consider autologous blood salvage
- Assign 1 person as primary contact for blood bank
- Activate massive transfusion protocol
Begin transfusion in 1 PRBC : 1 FFP : 1 Platelet
- Calcium repletion for massive transfusion
- Fibrinogen replacement as indicated
Consider TXA administration
Warm patient and fluids
Discuss management plan with surgical, anesthesiology, and nursing teams
- Call for additional surgery consultation as indicated
- Consider damage control surgery (pack, close, resuscitate)
- Consider resuscitative endovascular balloon occlusion of the aorta (REBOA) for hemorrhage below the diaphragm
- Consider ECMO or cardiac bypass to facilitate surgical repair
Send labs
- CBC, PT / PTT / INR, fibrinogen, lactate, arterial blood gas, potassium, and ionized calcium
- Viscoelastography
Consider re-dosing antibiotics if EBL > 1500 mL
Drugs
| Tranexamic Acid (TXA) | BOLUS: 1 g IV |
|---|---|
| Tranexamic Acid (TXA) | Over 10 min |
| Tranexamic Acid (TXA) | INFUSION: 1 g/500 mL |
| Tranexamic Acid (TXA) | Over 8 hours |
| Calcium Gluconate / Calcium Chloride | 1 g per 3 units product1 g per 5 units product |
| Calcium Gluconate / Calcium Chloride | Adjust to measured ionized calcium |
| Insulin (Regular) + Dextrose | 5 - 10 units IV 50 - 100 mL D50W IV- or -250 - 500 mL D10W IV |
| Sodium bicarbonate (if pH <7.2) | 50 mEq IV |