Delayed Emergence
ADU-06
Diagnosis
Prolonged unresponsiveness following general anesthesia or abnormal neurologic exam following general anesthesia
Call for help
- Ask: "Who will be the crisis manager?"
- Crisis manager designates checklist reader
Ensure all anesthetic medications have been stopped
Check for and correct hypoxemia, hypercarbia, hypothermia, or hypotension
- Consider signs of increased intracranial pressure (widened pulse pressure, bradycardia, irregular respirations)
Check for and treat residual drug effects
- Neuromuscular blockade (check TOF)
- Opiates and hypnotics
Send labs
- Arterial blood gas, electrolytes, glucose
Correct electrolyte, glucose abnormalities
Perform neurologic examination
- If unresponsive: pupil changes, gag reflex, level of arousal
- If responsive: stroke assessment
- Facial droop - show teeth in smile
- Pronator drift - eyes closed, extend arms with palms up for 10 seconds
- Speech assessment - say “you can’t teach old dogs new tricks”
- Assess for severe sudden headache
- Consider STAT head CT and neurology consult for abnormal exam
Drugs
| Naloxone | 40 MICROgrams IV |
|---|---|
| Naloxone | (0.4 mg to total 10 mL = 40 MICROgrams/mL) |
| Naloxone | Repeat q 2 minutes |
| Naloxone | If no response to 400 MICROgrams, consider non-opiate causes |
| Flumazenil | 0.2 mg IV |
| Flumazenil | Repeat dose q 1 minute |
| Flumazenil | Max dose 1 mg |
| Flumazenil | AVOID in chronic benzodiazepine use or seizure history |
| Sugammadex | 2 - 4 mg/kg IV |
DIFFERENTIAL diagnosis
- Serotonin syndrome
- Myxedema coma or thyroid storm
- Concomitant head injury
- Hepatic or uremic encephalopathy
- Neurosurgical complications
- Hemorrhage
- Vascular occlusion
- Elevated ICP
- Postictal state following intraoperative seizure
- Medication error
- Local Anesthetic Systemic Toxicity (ADU-12)
- Central anticholinergic syndrome