Acute Hypertension
PED-11
Diagnosis
Sustained high blood pressure refractory to treating reversible causes
Hypertensive Blood Pressure Range
- Age (yr) · Systolic · Diastolic
- newborn · > 97 · > 70
- 1-3 · > 105 · > 61
- 4-12 · > 113 · > 86
In pediatrics, hypertension is almost always treated by addressing likely causes such as light anesthesia or measurement error
- Ensure correct BP cuff size: cuff bladder width ~40% of limb circumference
- Ensure arterial line transducer is at level of heart; Consider placing arterial line if not already present
CAUTION: Anti-hypertensive drugs are almost never needed for routine pediatric cases and are used almost exclusively for specialized cardiac, neurosurgical, or endocrine (pheochromocytoma) cases. Consult an expert before use. Rule-out increased ICP.
For direct smooth muscle relaxation, consider
- Sodium nitroprusside 0.5-10 MICROgrams/kg/min infusion
- Hydralazine 0.1-0.2 mg/kg (adult dose 5-10 mg)
For β-Adrenergic blockade, consider
- Esmolol 100-500 MICROgrams/kg over 5 min, then 25-300 MICROgrams/kg/min infusion
- Labetalol (also α effect) 0.2-1 mg/kg q 10 min; 0.4-3 mg/kg/hour infusion
For calcium channel blockade, consider
- Nicardapine 0.5-5 MICROgrams/kg/min
- Clevidipine 0.5-3.5 MICROgrams/kg/min
For D1-dopamine agonist, consider
- Fenoldopam 0.2-0.8 MICROgrams/kg/min
Crisis Management (If Severe)
Notify surgeon, call for help and code cart
Call for Transesophageal Echocardiography
Start chest compressions
Give epinephrine 10 MICROgrams/kg IV/IO
If cardiac arrest, go to CARDIAC ARREST
Consider ECMO
Drugs
| Sodium nitroprusside | 0.5-10 MICROgrams/kg/min |
|---|---|
| Hydralazine | 0.1-0.2 mg/kg (adult dose 5-10 mg) |
| Esmolol | 100-500 MICROgrams/kg over 5 min |
| Esmolol | Then infusion 25-300 MICROgrams/kg/min |
| Labetalol | 0.2-1 mg/kg q 10 min |
| Labetalol | Then infusion 0.4-3 mg/kg/hour |
| Nicardapine | 0.5-5 MICROgrams/kg/min |
| Clevidipine | 0.5-3.5 MICROgrams/kg/min |
| Fenoldopam | 0.2-0.8 MICROgrams/kg/min |
Differential (Partial)
- Light anesthesia (consider vaporizer or infusion pump empty or malfunctioning)
- Hypercarbia
- Hypoxemia
- Arterial line transducer too low or BP cuff too small
- Withdrawal (EtOH or opioid)
- Thyroid storm
- Pheochromocytoma
- Drug error